Why are diabetes, heart disease, hypertertension, and obesity risk factors for mortality from COVID-19?

Diabetes, coronary artery disease, hypertension, obesity are the main “underlying medical conditions” that increase risk of death from Covid19. Does this sound familiar? All are features of metabolic syndrome.  And what is the overarching pathophysiology of metabolic syndrome? Hyperinsulinemia. Hypertension, one of the strong predictors of a bad outcome with Covid19 is not, in an of itself, necessarily associated with impaired immunity.  Most cases of hypertension are associated with metabolic syndrome and hyperinsulinemia. It is not universally agreed, but a, if not the, primary mechanism for the association of hyperinsulinemia and hypertension is the upregulation of the renin, angiotensin, aldosterone, RAAS, system.  One mechanism whereby insulin upregulates the RAAS system is by upregulating ACE receptors.  See links to articles below.  SARS-CoV-2 virus enters cells by attaching to the ACE receptor in lungs.  So it should follow that the more active ACE receptors an individual has, the more opportunity the SARS-CoV-2 virus has to penetrate lung tissue leading to worse disease and mortality. According to a review of NHANES data, 88% of US population is metabolically unhealthy. If you want to improve your chances of surviving Covid19, you need to reverse your metabolic syndrome with a low carb, ketogenic diet.

https://europepmc.org/article/med/15106803

https://www.ahajournals.org/doi/10.1161/01.ATV.0000254814.63768.3b

https://www.ncbi.nlm.nih.gov/pubmed/25115697

https://www.sciencedaily.com/releases/2018/11/181128115045.htm

Low Carb Ketogenic Diet For Weight Loss and Diabetes Control–Getting Started

Quick start Low Carb Ketogenic Diet guide:

Why carbohydrate restriction rather than total calories or fats?

In a nutshell: It’s about insulin.  Insulin has two main functions.  1. It enables glucose to enter cells so they can utilize it for energy. 2. It promotes the deposition of fat into the bodies fat stores. The higher the insulin level, the more fat is deposited into and locked into fat stores.  Carbohydrates are the primary food type that stimulates insulin release. Eating foods very high in sugar and refined carbohydrates causes significant spikes in insulin levels which not only cause more storage of the food you just ate into fat, but also adversely affects your liver and muscle tissues over time causing these organs to become resistant to insulin.

Read More